Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.72 |
| ▸ | RAB9A | P51151 | 6/20 | 0.72 |
| ▸ | DHODH | Q02127 | 5/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272537 | 0.87 | RAB9A (0.72) | MEN1KMT2ARAB9ADHODHSMN1; SMN2 | |
| SCHEMBL22445163 | 0.87 | RAB9A (0.60) | MEN1KMT2ARAB9ADHODHSMN1; SMN2 | |
| SCHEMBL8027592 | 0.87 | RAB9A (0.60) | MEN1KMT2ARAB9ADHODHSMN1; SMN2 | |
| SCHEMBL7281512 | 0.87 | DHODH (0.71) | MEN1KMT2ARAB9ADHODHSMN1; SMN2 | |
| SCHEMBL12478838 | 0.87 | RAB9A (0.65) | MEN1KMT2ARAB9ADHODHSMN1; SMN2 | |
| SCHEMBL15636015 | 0.86 | DHODH (0.72) | MEN1KMT2ARAB9ADHODHSMN1; SMN2 | |
| SCHEMBL22453338 | 0.86 | RAB9A (0.59) | MEN1KMT2ARAB9ADHODHSMN1; SMN2 | |
| SCHEMBL7278408 | 0.86 | RAB9A (0.80) | MEN1KMT2ARAB9ADHODHSMN1; SMN2 | |
| SCHEMBL16616388 | 0.85 | RAB9A (0.76) | MEN1KMT2ARAB9ADHODHSMN1; SMN2 | |
| SCHEMBL7271426 | 0.85 | MEN1 (0.58) | MEN1KMT2ARAB9ADHODHSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182289-A | Pyrrolo 2,3-b!Pyridin-2-one Derivatives | SCHERING CORPORATION (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0419561-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1991-04-03 | — | — | EP | disclosed |
| WO-1989012637-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0347698-A1 | Heterobicyclic compounds having antiinflammatory activity | SCHERING CORPORATION (US) | 1989-12-27 | — | — | EP | disclosed |