Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 9/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | AHR | P35869 | 1/20 | 0.55 |
| ▸ | DHODH | Q02127 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8027592 | 0.87 | RAB9A (0.60) | RAB9ANPC1ALDH1A1NPSR1HTT | |
| SCHEMBL22445163 | 0.87 | RAB9A (0.60) | RAB9ANPC1ALDH1A1NPSR1HTT | |
| SCHEMBL7272537 | 0.87 | RAB9A (0.72) | RAB9ANPC1ALDH1A1NPSR1HTT | |
| SCHEMBL7281512 | 0.87 | DHODH (0.71) | RAB9ANPC1ALDH1A1NPSR1HTT | |
| SCHEMBL9469649 | 0.86 | MEN1 (0.72) | RAB9ANPC1ALDH1A1NPSR1HTT | |
| SCHEMBL15636015 | 0.86 | DHODH (0.72) | RAB9ANPC1ALDH1A1NPSR1HTT | |
| SCHEMBL7278408 | 0.86 | RAB9A (0.80) | RAB9ANPC1ALDH1A1NPSR1HTT | |
| SCHEMBL22452840 | 0.85 | MEN1 (0.58) | RAB9ANPC1ALDH1A1NPSR1HTT | |
| SCHEMBL22453414 | 0.84 | RAB9A (0.65) | RAB9ANPC1ALDH1A1NPSR1HTT | |
| SCHEMBL3807873 | 0.84 | DHODH (0.77) | RAB9ANPC1ALDH1A1NPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |