Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | DHODH | Q02127 | 3/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 2/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9488233 | 0.86 | DHODH (0.55) | RAB9AMEN1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL10488476 | 0.73 | LRRK2 (0.50) | RAB9AMEN1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL7761071 | 0.73 | CYP1A2 (0.51) | MAPTALDH1A1MAPKAPK2CSNK2A1 | |
| SCHEMBL9469395 | 0.73 | DHODH (1.00) | RAB9AMEN1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL1505140 | 0.72 | SMN1; SMN2 (0.53) | MEN1KMT2ASMN1; SMN2DHODHLMNA | |
| Hydrochloric Acid SCHEMBL10561182 | 0.71 | SMN1; SMN2 (0.52) | MEN1KMT2ASMN1; SMN2DHODHLMNA | |
| SCHEMBL16616388 | 0.69 | RAB9A (0.76) | RAB9AMEN1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL29305913 | 0.69 | RAB9A (0.58) | RAB9AMEN1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL11265251 | 0.69 | POLB (0.53) | RAB9AMEN1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL353204 | 0.68 | KDM4E (0.40) | KMT2ASMN1; SMN2MAPTLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182289-A | Pyrrolo 2,3-b!Pyridin-2-one Derivatives | SCHERING CORPORATION (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0419561-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1991-04-03 | — | — | EP | disclosed |
| WO-1989012637-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0347698-A1 | Heterobicyclic compounds having antiinflammatory activity | SCHERING CORPORATION (US) | 1989-12-27 | — | — | EP | disclosed |