Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469652 | 0.86 | RAB9A (0.57) | DHODHMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL5133830 | 0.78 | KMT2A (0.50) | DHODHMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL7834036 | 0.77 | BDKRB1 (0.50) | KMT2AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL7443977 | 0.75 | NOS3 (0.47) | DHODHMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL7761071 | 0.74 | CYP1A2 (0.51) | MAPTALDH1A1MAPK1EGFRITK | |
| Hydrochloric Acid SCHEMBL11127891 | 0.73 | NOS3 (0.46) | DHODHMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL4134533 | 0.73 | DHODH (0.62) | DHODHMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL13861455 | 0.72 | PDE4B (0.50) | DHODHMEN1KMT2ARAB9AMAPT | |
| SCHEMBL10814167 | 0.72 | MAPT (0.57) | DHODHMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL7236672 | 0.72 | NPC1 (0.60) | DHODHMEN1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5180823-A | Processes for preparing bicyclic compounds | SCHERING CORPORATION (US) | 1993-01-19 | — | — | US | disclosed |
| US-5079360-A | Processes for preparing bicyclic compounds and intermediates thereof | SCHERING CORPORATION (US) | 1992-01-07 | — | — | US | disclosed |
| US-4902693-A | Anti-allergic esters, acetal ethers, thioethers and nitrogen substituted derivatives of bicyclic compounds | SCHERING CORPORATION (US) | 1990-02-20 | — | — | US | disclosed |
| US-4897487-A | Process for preparing intermediates for pharmaceutically useful bicyclic compounds | SCHERING CORPORATION (US) | 1990-01-30 | — | — | US | disclosed |
| US-4794116-A | ANTIINFLAMMATORY AGENTS, CYTOPROTECTIVE AGENTS IN TREATMENT OF HYPERPROLIFERATIVE SKIN DISEASE | SCHERING CORPORATION (US) | 1988-12-27 | — | — | US | disclosed |
| US-4782067-A | Anti-allergic composition containing zwitterionic bicyclic compounds | SCHERING CORPORATION (US) | 1988-11-01 | — | — | US | disclosed |
| US-4551463-A | ANTIULCER | SCHERING CORPORATION (US) | 1985-11-05 | — | — | US | disclosed |