Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27540417 | 0.84 | LTA4H (0.46) | SYKALDH1A1KMT2APOLBLTA4H | |
| SCHEMBL27639138 | 0.81 | ALDH1A1 (0.47) | SYKALDH1A1KMT2APOLBLTA4H | |
| SCHEMBL16419678 | 0.81 | ALDH1A1 (0.48) | SYKALDH1A1TSHRL3MBTL1 | |
| SCHEMBL17464243 | 0.80 | KLK7 (0.65) | KLK7SYKMMEANPEPALDH1A1 | |
| SCHEMBL12873043 | 0.80 | KLK7 (0.65) | KLK7SYKMMEANPEPALDH1A1 | |
| SCHEMBL3736721 | 0.80 | RNPEP (0.47) | KLK7ALDH1A1TSHRMEN1LMNA | |
| SCHEMBL3736726 | 0.80 | RNPEP (0.47) | KLK7ALDH1A1TSHRMEN1LMNA | |
| SCHEMBL23363906 | 0.80 | ALDH1A1 (0.46) | SYKALDH1A1KMT2APOLBLTA4H | |
| SCHEMBL28531197 | 0.80 | ALDH1A1 (0.49) | SYKALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL30019078 | 0.79 | ALDH1A1 (0.42) | SYKALDH1A1MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5192800-A | Hypotensive agents | PFIZER INC. (US) | 1993-03-09 | — | — | US | disclosed |
| US-5030654-A | Glutaramide diuretic agents | PFIZER INC. (US) | 1991-07-09 | — | — | US | disclosed |
| EP-0274234-A2 | Spiro-subsituted glutaramide diuretic agents | Pfizer Limited (GB) | 1988-07-13 | — | — | EP | disclosed |