3-Nitro-Phenol

3-Nitro-Phenol

SCHEMBL9470484

Cc1ccc(S(=O)(=O)O)cc1.N#N.O=[N+]([O-])c1cccc(O)c1

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of 3-Nitro-Phenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.61
ALDH1A1 P00352 3/20 0.61
ALOX15 P16050 1/20 0.61
KMT2A Q03164 3/20 0.49
CYP1A2 P05177 2/20 0.49
CYP3A4 P08684 2/20 0.49
CYP2C19 P33261 1/20 0.49
ACHE P22303 2/20 0.49
NFE2L2 Q16236 1/20 0.47
GAA P10253 2/20 0.46
HTT P42858 1/20 0.46
POLB P06746 1/20 0.46
LMNA P02545 2/20 0.46
CA2 P00918 2/20 0.44
CA1 P00915 1/20 0.44
MMP1 P03956 1/20 0.44
MMP2 P08253 1/20 0.44
MMP9 P14780 1/20 0.44
MMP8 P22894 1/20 0.44
MMP13 P45452 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dinitrophenylene SCHEMBL9007683 0.88 TSHR (0.58) TSHRALDH1A1ALOX15KMT2ACYP1A2
Dinitrophenylene SCHEMBL29222862 0.84 TSHR (0.57) TSHRALDH1A1KMT2ACYP1A2CYP3A4
P-Nitrophenol SCHEMBL9470520 0.82 ACHE (0.56) ALDH1A1KMT2AACHEGAALMNA
3-Nitro-Phenol SCHEMBL28727747 0.82 TSHR (0.85) TSHRALDH1A1ALOX15KMT2AACHE
SCHEMBL18423828 0.82 KMT2A (0.50) TSHRALDH1A1KMT2ACYP1A2CYP3A4
Nitrobenzene SCHEMBL660753 0.81 ACHE (0.57) TSHRALDH1A1KMT2ACYP1A2CYP3A4
3-Nitro-Phenol SCHEMBL29556708 0.80 TSHR (0.96) TSHRALDH1A1ALOX15KMT2AACHE
Metacresol SCHEMBL4408619 0.79 ACHE (0.61) TSHRALDH1A1KMT2ACYP1A2CYP2C19
SCHEMBL19272432 0.78 ACHE (0.69) ALDH1A1KMT2AACHEGAACA2
3-Nitro-Phenol SCHEMBL9471143 0.78 TSHR (0.67) TSHRALDH1A1ALOX15KMT2AACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5186865-A Aminoazobenzene derivatives and polymers ALLIED-SIGNAL INC. (US) 1993-02-16 US disclosed
US-5061404-A WAVEGUIDES ALLIED-SIGNAL INC. (US) 1991-10-29 US disclosed
US-5036142-A Reaction of diazonium salt with addition polymer containing aminophenyl group ALLIED-SIGNAL INC. (US) 1991-07-30 US disclosed
WO-1991009842-A1 ELECTRO-OPTICAL MATERIALS AND LIGHT MODULATOR DEVICES CONTAINING SAME ALLIED-SIGNAL INC. (US) 1991-07-11 WO disclosed
WO-1991009885-A2 PROCESS FOR MAKING ELECTRO-OPTICALLY ACTIVE POLYMERS ALLIED-SIGNAL INC. (US) 1991-07-11 WO disclosed