Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27275066 | 0.85 | ALDH1A1 (0.51) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL21508984 | 0.85 | ALDH1A1 (0.51) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL13445873 | 0.83 | TDP1 (0.44) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL19105243 | 0.83 | ALDH1A1 (0.56) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL17724576 | 0.83 | CHRM1 (0.49) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL28428867 | 0.81 | ALDH1A1 (0.53) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL28274065 | 0.81 | ALDH1A1 (0.50) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL26757958 | 0.80 | ALDH1A1 (0.53) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL19105272 | 0.80 | ALDH1A1 (0.55) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A | |
| SCHEMBL15177646 | 0.80 | HTT (0.49) | ALDH1A1TDP1MAPK1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5192800-A | Hypotensive agents | PFIZER INC. (US) | 1993-03-09 | — | — | US | disclosed |
| EP-0274234-B1 | SPIRO-SUBSITUTED GLUTARAMIDE DIURETIC AGENTS | Pfizer Limited (GB) | 1991-09-11 | — | — | EP | disclosed |
| US-5030654-A | Glutaramide diuretic agents | PFIZER INC. (US) | 1991-07-09 | — | — | US | disclosed |
| EP-0274234-A2 | Spiro-subsituted glutaramide diuretic agents | Pfizer Limited (GB) | 1988-07-13 | — | — | EP | disclosed |