Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 6/20 | 0.40 |
| ▸ | PPARA | Q07869 | 6/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | ACP3 | P15309 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11347968 | 0.81 | PPARG (0.42) | CHRM1KMT2APPARGPPARACYP1A2 | |
| SCHEMBL11704440 | 0.80 | CTSB (0.46) | CYP1A2 | |
| SCHEMBL1484444 | 0.76 | CPA1 (0.46) | CHRM1PPARGPPARACYP1A2SRR | |
| SCHEMBL3206845 | 0.75 | CYP1A2 (0.46) | CHRM1KMT2ACYP1A2CYP2D6SRR | |
| SCHEMBL15899458 | 0.74 | HPGD (0.46) | CHRM1KMT2AHPGDTSHR | |
| SCHEMBL29740764 | 0.74 | PABPC1 (0.54) | CHRM1KMT2ACYP1A2TSHRSRR | |
| SCHEMBL29740763 | 0.74 | PABPC1 (0.54) | CHRM1KMT2ACYP1A2TSHRSRR | |
| Bicarbonate SCHEMBL28105724 | 0.74 | EPHX1 (0.49) | CHRM1KMT2APPARGPPARACYP1A2 | |
| SCHEMBL27695662 | 0.74 | CYP1A2 (0.49) | PPARGPPARACYP1A2MMP8SRR | |
| SCHEMBL9067637 | 0.73 | EPHX1 (0.52) | CHRM1CYP1A2CYP2D6SRREPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5192800-A | Hypotensive agents | PFIZER INC. (US) | 1993-03-09 | — | — | US | disclosed |
| EP-0274234-B1 | SPIRO-SUBSITUTED GLUTARAMIDE DIURETIC AGENTS | Pfizer Limited (GB) | 1991-09-11 | — | — | EP | disclosed |
| US-5030654-A | Glutaramide diuretic agents | PFIZER INC. (US) | 1991-07-09 | — | — | US | disclosed |
| EP-0274234-A2 | Spiro-subsituted glutaramide diuretic agents | Pfizer Limited (GB) | 1988-07-13 | — | — | EP | disclosed |