Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CHKA | P35790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5863 | 0.84 | SIGMAR1 (0.56) | SIGMAR1CHRM5CHRM3ALDH1A1MEN1 | |
| Piperazine SCHEMBL28845954 | 0.82 | SIGMAR1 (0.54) | SIGMAR1CHRM5CHRM3ALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL17271878 | 0.82 | ALDH1A1 (0.54) | SIGMAR1CHRM5CHRM3ALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL963162 | 0.82 | ALDH1A1 (0.54) | SIGMAR1CHRM5CHRM3ALDH1A1MEN1 | |
| SCHEMBL2004972 | 0.81 | SIGMAR1 (0.50) | SIGMAR1CHRM5CHRM3ALDH1A1MEN1 | |
| SCHEMBL28760423 | 0.81 | SIGMAR1 (0.40) | SIGMAR1CHRM5CHRM3ALDH1A1MEN1 | |
| SCHEMBL8393969 | 0.81 | SIGMAR1 (0.53) | SIGMAR1CHRM5CHRM3ALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL2008568 | 0.80 | SIGMAR1 (0.49) | SIGMAR1CHRM5CHRM3ALDH1A1MEN1 | |
| SCHEMBL665674 | 0.79 | SIGMAR1 (0.61) | SIGMAR1CHRM5CHRM3ALDH1A1MEN1 | |
| SCHEMBL2010851 | 0.79 | CHRM5 (0.54) | SIGMAR1CHRM5CHRM3ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611777-B1 | N-(4-{[PYRIDIN-3-YL-METHYL)CARBAMOYL]AMINO}BENZENE-SULFONE DERIVATIVES AS NAMPT INHIBITORS FOR THERAPY OF DISEASES SUCH AS CANCER | FORMA TM LLC (US) | 2016-05-11 | — | — | EP | disclosed |
| US-5189161-A | Analgesics | HOECHST ROUSSEL PHARMACEUTICALS INC. (US) | 1993-02-23 | — | — | US | disclosed |
| US-5015738-A | Analgesics | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-05-14 | — | — | US | disclosed |
| US-4983601-A | Analgesics | HOECHST-ROUSSEL PHARMACEUTICAL INC. (US) | 1991-01-08 | — | — | US | disclosed |