Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 7/20 | 0.63 |
| ▸ | GSK3B | P49841 | 7/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1722780 | 0.77 | GSK3B (0.71) | GSK3AGSK3BKMT2ATSHRLMNA | |
| SCHEMBL15354264 | 0.73 | GSK3B (1.00) | GSK3AGSK3BTSHRLMNAGAA | |
| SCHEMBL3906792 | 0.72 | GSK3A (0.46) | GSK3AGSK3BKMT2ATSHRLMNA | |
| SCHEMBL5199351 | 0.71 | GSK3B (0.71) | GSK3AGSK3BKMT2ATSHRLMNA | |
| SCHEMBL23743947 | 0.69 | KMT2A (1.00) | KMT2ATSHRLMNAGAAMAPK1 | |
| SCHEMBL9472997 | 0.68 | GSK3A (0.48) | GSK3AGSK3BTSHRLMNAGAA | |
| SCHEMBL11768682 | 0.68 | GSK3A (0.50) | GSK3AGSK3BKMT2ATSHRLMNA | |
| SCHEMBL30976973 | 0.68 | APEX1 (0.63) | GSK3AGSK3BKMT2ATSHRLMNA | |
| SCHEMBL11156963 | 0.67 | GSK3B (0.58) | GSK3AGSK3BKMT2ATSHRLMNA | |
| SCHEMBL11096145 | 0.67 | GSK3B (0.58) | GSK3AGSK3BKMT2ATSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990000897-A1 | METHOD FOR THE CONTROL OF HYPERLIPIDEMIA | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1990-02-08 | — | — | WO | claimed |
| US-4866058-A | TRIAZOLIDINE-BIONES, TRIAZABICYCLOHEXANEDIONES, AND TRIAZINE-DIONES | NORTH CAROLINA AT CHAPEL HILL, THE UNIVERSITY OF | 1989-09-12 | — | — | US | claimed |
| US-5192761-A | 1,2,4-triazolidine-3,5-diones and 1,3,5-triazine-2,4(1-H,3H)-diones, pharmaceutical compositions | NORTH CAROLINA CENTRAL UNIV. (US) | 1993-03-09 | — | — | US | disclosed |
| US-5034528-A | 1,3,5-triazabicyclo 3.1.0!hexane-3,5-diones | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 1991-07-23 | — | — | US | disclosed |
| WO-1990000897-A1 | METHOD FOR THE CONTROL OF HYPERLIPIDEMIA | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1990-02-08 | — | — | WO | disclosed |
| US-4866058-A | TRIAZOLIDINE-BIONES, TRIAZABICYCLOHEXANEDIONES, AND TRIAZINE-DIONES | NORTH CAROLINA AT CHAPEL HILL, THE UNIVERSITY OF | 1989-09-12 | — | — | US | disclosed |