Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MMP12 | P39900 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9472221 | 0.94 | POLB (0.66) | POLBLMNAKMT2AALDH1A1CYP2D6 | |
| SCHEMBL8931470 | 0.90 | POLB (0.79) | POLBLMNAKMT2AALDH1A1CYP2D6 | |
| SCHEMBL21097453 | 0.90 | POLB (0.79) | POLBLMNAKMT2AALDH1A1CYP2D6 | |
| SCHEMBL8931476 | 0.90 | POLB (0.79) | POLBLMNAKMT2AALDH1A1CYP2D6 | |
| SCHEMBL9472639 | 0.89 | POLB (0.53) | POLBLMNAKMT2AALDH1A1CYP2D6 | |
| SCHEMBL9472933 | 0.88 | POLB (0.51) | POLBLMNAKMT2AALDH1A1CYP2D6 | |
| SCHEMBL8332380 | 0.87 | POLB (0.49) | POLBLMNAKMT2AL3MBTL1 | |
| SCHEMBL11274431 | 0.87 | POLB (0.53) | POLBLMNAKMT2AALDH1A1CYP2D6 | |
| SCHEMBL9472730 | 0.86 | CYP2D6 (0.51) | POLBLMNAKMT2AALDH1A1CYP2D6 | |
| SCHEMBL11265381 | 0.85 | POLB (0.54) | POLBLMNAKMT2AALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5264431-A | Inhibitors for proteinkinase C | CIBA-GEIGY CORP. (US) | 1993-11-23 | — | — | US | disclosed |