Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 9/20 | 0.66 |
| ▸ | CACNA1D | Q01668 | 9/20 | 0.66 |
| ▸ | CACNA1S | Q13698 | 9/20 | 0.66 |
| ▸ | CACNA1C | Q13936 | 9/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | SCN1A | P35498 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9475596 | 0.91 | CACNA1C (0.68) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL9475454 | 0.88 | CACNA1D (0.53) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL9475779 | 0.86 | CACNA1D (0.58) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL9475842 | 0.83 | CACNA1F (0.47) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL10358732 | 0.82 | CACNA1D (0.58) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL10557782 | 0.81 | CACNA1F (0.54) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL9477065 | 0.81 | CACNA1F (0.67) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL9474962 | 0.81 | CACNA1F (0.63) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL9475098 | 0.79 | CACNA1C (0.57) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL9475672 | 0.79 | CACNA1F (0.44) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202330-A | Hypotensive and cardiovascular agent, reduces blood pressure in mammals | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0204317-A2 | 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1986-12-10 | — | — | EP | disclosed |