Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1D | Q01668 | 8/20 | 0.58 |
| ▸ | CACNA1F | O60840 | 7/20 | 0.58 |
| ▸ | CACNA1S | Q13698 | 7/20 | 0.58 |
| ▸ | CACNA1C | Q13936 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.43 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9476298 | 0.90 | CACNA1D (0.48) | CACNA1DCACNA1FCACNA1SCACNA1CMAPT | |
| SCHEMBL9475008 | 0.86 | CACNA1F (0.66) | CACNA1DCACNA1FCACNA1SCACNA1CMAPT | |
| SCHEMBL9475596 | 0.78 | CACNA1C (0.68) | CACNA1DCACNA1FCACNA1SCACNA1CMAPT | |
| SCHEMBL9475454 | 0.77 | CACNA1D (0.53) | CACNA1DCACNA1FCACNA1SCACNA1CMAPT | |
| SCHEMBL10557782 | 0.77 | CACNA1F (0.54) | CACNA1DCACNA1FCACNA1SCACNA1CMAPT | |
| SCHEMBL10358732 | 0.76 | CACNA1D (0.58) | CACNA1DCACNA1FCACNA1SCACNA1CMAPT | |
| SCHEMBL9477065 | 0.75 | CACNA1F (0.67) | CACNA1DCACNA1FCACNA1SCACNA1CMAPT | |
| SCHEMBL4608748 | 0.70 | CACNA1C (0.73) | CACNA1DCACNA1FCACNA1SCACNA1CMAPT | |
| SCHEMBL612520 | 0.70 | CACNA1C (0.73) | CACNA1DCACNA1FCACNA1SCACNA1CMAPT | |
| SCHEMBL9474962 | 0.70 | CACNA1F (0.63) | CACNA1DCACNA1FCACNA1SCACNA1CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202330-A | Hypotensive and cardiovascular agent, reduces blood pressure in mammals | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0204317-A2 | 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1986-12-10 | — | — | EP | disclosed |