Sugi Predict

Sugi Predict / Compounds / SCHEMBL9475196

SCHEMBL9475196

SCHEMBL9475196

Cc1cccc2c1CNC2=O

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PARP1 P09874 4/20 0.68
▸ PARP10 Q53GL7 2/20 0.68
▸ PARP11 Q9NR21 2/20 0.68
▸ CLK4 Q9HAZ1 4/20 0.61
▸ ROCK1 Q13464 4/20 0.61
▸ PIM1 P11309 3/20 0.61
▸ CDK5 Q00535 2/20 0.61
▸ DYRK1A Q13627 2/20 0.61
▸ CSNK1A1 P48729 1/20 0.61
▸ LRRK2 Q5S007 1/20 0.61
▸ DYRK1B Q9Y463 1/20 0.61
▸ LTK P29376 1/20 0.53
▸ MST1R Q04912 1/20 0.53
▸ KDR P35968 7/20 0.50
▸ CA12 O43570 1/20 0.48
▸ CA9 Q16790 1/20 0.48
▸ ROCK2 O75116 3/20 0.48
▸ MAP4K4 O95819 3/20 0.48
▸ LCK P06239 3/20 0.48
▸ RET P07949 3/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30331787 1.00 PARP1 (0.68) PARP1PARP10PARP11CLK4ROCK1
SCHEMBL30775244 0.87 PARP10 (0.57) PARP1PARP10PARP11CLK4ROCK1
SCHEMBL29687894 0.81 PARP1 (1.00) PARP1PARP10PARP11ACHE
SCHEMBL831538 0.81 PARP1 (1.00) PARP1PARP10PARP11ACHE
SCHEMBL18333644 0.80 PARP1 (0.50) PARP1PARP10PARP11CLK4ROCK1
SCHEMBL30775313 0.79 CLK4 (0.53) PARP1PARP10PARP11CLK4ROCK1
SCHEMBL6297545 0.78 PARP1 (0.70) PARP1PARP10PARP11CLK4ROCK1
SCHEMBL29532218 0.78 PARP1 (0.70) PARP1PARP10PARP11CLK4ROCK1
SCHEMBL12219092 0.77 CDK5 (0.58) PARP1PARP10PARP11CLK4ROCK1
SCHEMBL30775196 0.77 CLK4 (0.49) PARP1PARP10PARP11CLK4ROCK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117088905-A Asymmetric boron-fluorine pyrrole fluorescent dye, preparation method thereof and method for preparing fluorescent microspheres 南京珀立科技有限公司 2023-11-21 — — CN claimed
CN-117088905-A Asymmetric boron-fluorine pyrrole fluorescent dye, preparation method thereof and method for preparing fluorescent microspheres 南京珀立科技有限公司 2023-11-21 — — CN disclosed
WO-2023158626-A1 ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE THEREOF MERCK SHARP & DOHME LLC (US) 2023-08-24 — — WO disclosed
US-11731953-B2 Methods and compounds for restoring mutant p53 function PMV PHARMACEUTICALS, INC. (US) 2023-08-22 — — US disclosed
US-11731953-B2 Methods and compounds for restoring mutant p53 function PMV PHARMACEUTICALS, INC. (US) 2023-08-22 — — US disclosed
WO-2023125944-A1 COMPOUND CONTAINING HETEROCYCLIC RING 正大天晴药业集团股份有限公司 2023-07-06 — — WO disclosed
US-20230056253-A1 METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION PMV PHARMACEUTICALS, INC. 2023-02-23 — — US disclosed
EP-3738961-B1 HETEROCYCLIC COMPOUND AS CSF-1R INHIBITOR AND USE THEREOF MEDSHINE DISCOVERY INC (CN) 2022-08-31 — — EP disclosed
US-11384065-B2 Heterocyclic compound as CSF-1R inhibitor and use thereof MEDSHINE DISCOVERY INC. (CN) 2022-07-12 — — US disclosed
EP-3954679-A2 AMIDE COMPOUNDS FOR THE TREATMENT OF HIV INFECTIONS Gilead Sciences, Inc. (US) 2022-02-16 — — EP disclosed
WO-2011138751-A2 HETEROCYCLIC DERIVATIVES AS ALK INHIBITORS PFIZER INC. (US) 2011-11-10 — — WO disclosed
US-20110275630-A1 ISOINDOLINONE KINASE INHIBITORS ABBOTT LABORATORIES (US) 2011-11-10 — — US disclosed
WO-2010123139-A1 ARYLCARBOXAMIDE DERIVATIVE HAVING SULFAMOYL GROUP 持田製薬株式会社 (JP) 2010-10-28 — — WO disclosed
US-20100152178-A1 IMIDAZOLE DERIVATIVES KYOWA HAKKO KIRIN CO., LTD. (JP) 2010-06-17 — — US disclosed
US-20100152178-A1 IMIDAZOLE DERIVATIVES KYOWA HAKKO KIRIN CO., LTD. (JP) 2010-06-17 — — US disclosed
US-20100076051-A1 ISOINDOLINONE KINASE INHIBITORS ABBOTT LABORATORIES (US) 2010-03-25 — — US disclosed
US-20090318436-A1 Fused heterocyclic derivatives and methods of use AMGEN INC. (US) 2009-12-24 — — US disclosed
EP-2090570-A1 IMIDAZOLE DERIVATIVE Kyowa Hakko Kirin Co., Ltd. (JP) 2009-08-19 — — EP disclosed
US-7273861-B2 Non-nucleoside reverse transcriptase inhibitors BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 2007-09-25 — — US disclosed
US-5254578-A Cardiovascular disorders SANKYO COMPANY, LIMITED (JP) 1993-10-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090318436-A1 Fused heterocyclic derivatives and methods of use HGF, HGFAC, MET PARP1 1457/4885PARP10 2251/4885PARP11 1564/4885
US-20230056253-A1 METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION TP53, TP53BP1, HRAS PARP1 1067/4885PARP10 1575/4885PARP11 924/4885
US-11731953-B2 Methods and compounds for restoring mutant p53 function TP53, TP53BP1, HRAS PARP1 1067/4885PARP10 1575/4885PARP11 924/4885
US-11384065-B2 Heterocyclic compound as CSF-1R inhibitor and use thereof CSF1R, CSF3R, IL1RN PARP1 4158/4885PARP10 4330/4885PARP11 3060/4885
US-20100152178-A1 IMIDAZOLE DERIVATIVES CNR1, CNR2, ARRB1 PARP1 4118/4885PARP10 3001/4885PARP11 2680/4885
US-20100076051-A1 ISOINDOLINONE KINASE INHIBITORS ABL1, LCK, MAP3K7 PARP1 1874/4885PARP10 1523/4885PARP11 1123/4885
US-20110275630-A1 ISOINDOLINONE KINASE INHIBITORS MAP3K7, MAP3K5, MAP3K20 PARP1 950/4885PARP10 879/4885PARP11 683/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.