Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL615452 | 0.80 | TRPM4 (0.54) | KMT2AMEN1CYP2A6ALDH1A1HIF1A | |
| SCHEMBL2286583 | 0.78 | CYP2C19 (0.51) | KMT2AMEN1RXFP1CYP2A6ALDH1A1 | |
| SCHEMBL31504060 | 0.77 | TRPM4 (0.63) | KMT2AMEN1RXFP1CYP2A6ALDH1A1 | |
| SCHEMBL12693896 | 0.77 | TRPM4 (0.63) | KMT2AMEN1RXFP1CYP2A6ALDH1A1 | |
| SCHEMBL2397529 | 0.76 | HTR2A (0.46) | CHEK1KMT2AMEN1RXFP1CYP2A6 | |
| SCHEMBL12256751 | 0.76 | CYP2A6 (0.43) | CHEK1KMT2AMEN1RXFP1CYP2A6 | |
| SCHEMBL19421373 | 0.76 | MEN1 (0.47) | KMT2AMEN1RXFP1CYP2A6ALDH1A1 | |
| SCHEMBL1229705 | 0.75 | ACP1 (0.42) | CHEK1KMT2AMEN1RXFP1CYP2A6 | |
| SCHEMBL723041 | 0.74 | HPRT1 (0.64) | KMT2AMEN1RXFP1CYP2A6ALDH1A1 | |
| SCHEMBL9477125 | 0.74 | ALDH1A1 (0.35) | KMT2AMEN1CYP2A6ALDH1A1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5196529-A | Grampositive antibacterial agents | MERCK & CO., INC. (US) | 1993-03-23 | — | — | US | disclosed |
| US-5177202-A | 2-phenanthrenyl-carbapenems | MERCK & CO., INC. (US) | 1993-01-05 | — | — | US | disclosed |
| EP-0464901-A2 | 2-phenanthrenyl carbapenems | MERCK & CO. INC. (US) | 1992-01-08 | — | — | EP | disclosed |
| EP-0463852-A2 | 2-Phenanthrenyl-carbapenem antibacterial agents | MERCK & CO. INC. (US) | 1992-01-02 | — | — | EP | disclosed |
| US-5004740-A | Carbapenicillin antibiotics | MERCK & CO., INC. (US) | 1991-04-02 | — | — | US | disclosed |
| US-5004739-A | Dehydropeptidase inhibitor | MERCK & CO., INC. (US) | 1991-04-02 | — | — | US | disclosed |