Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.70 |
| ▸ | MAOB | P27338 | 3/20 | 0.64 |
| ▸ | MAOA | P21397 | 2/20 | 0.64 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.58 |
| ▸ | DAO | P14920 | 2/20 | 0.56 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3228582 | 0.91 | APP (0.82) | APPMAOBMAOADAOIDO1 | |
| SCHEMBL19059386 | 0.85 | APP (0.74) | APPMAOBMAOADAOIDO1 | |
| SCHEMBL11044221 | 0.85 | APP (0.74) | APPMAOBMAOADAOIDO1 | |
| SCHEMBL3241580 | 0.84 | MEN1 (0.50) | APPMAOBMAOAESR2MAPT | |
| SCHEMBL28526426 | 0.84 | APP (0.72) | APPMAOBMAOADAOHDAC3 | |
| SCHEMBL23961327 | 0.83 | CALM1 (0.63) | APPCALM1LTA4HESR2IDO1 | |
| SCHEMBL8406865 | 0.83 | CALM1 (0.63) | APPCALM1DAOLTA4HESR2 | |
| SCHEMBL18475586 | 0.82 | APP (1.00) | APPMAOBMAOADAOIDO1 | |
| SCHEMBL12945246 | 0.82 | APP (0.70) | APPMAOBMAOADAOIDO1 | |
| SCHEMBL11044220 | 0.82 | APP (0.70) | APPMAOBMAOADAOIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5254578-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1993-10-19 | — | — | US | disclosed |
| EP-0482931-A1 | Benzopyran derivatives having anti-hypertensive and vasodilatory activity, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1992-04-29 | — | — | EP | disclosed |