SCHEMBL9475651

SCHEMBL9475651

CCOC(=O)C(OCC)(OCC)c1ccc(Oc2ccccc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.51
RAB9A P51151 3/20 0.51
HPGD P15428 1/20 0.51
CRHBP P24387 1/20 0.51
CRHR2 Q13324 1/20 0.51
ALDH1A1 P00352 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
LMNA P02545 2/20 0.45
MAPT P10636 2/20 0.45
HTT P42858 1/20 0.45
THRB P10828 1/20 0.45
LTA4H P09960 1/20 0.45
PIN1 Q13526 1/20 0.44
POLB P06746 1/20 0.43
CYP2C9 P11712 1/20 0.43
PTGS2 P35354 1/20 0.42
SCN9A Q15858 1/20 0.41
PPARA Q07869 2/20 0.41
PPARG P37231 1/20 0.41
MAPK14 Q16539 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9475755 0.88 NPC1 (0.51) NPC1RAB9AHPGDCRHBPCRHR2
SCHEMBL9475853 0.88 NPC1 (0.48) NPC1RAB9AHPGDCRHBPCRHR2
SCHEMBL9474980 0.86 NPC1 (0.44) NPC1RAB9AHPGDCRHBPCRHR2
SCHEMBL9476928 0.83 ALDH1A1 (0.48) HPGDALDH1A1LMNAMAPTPOLB
SCHEMBL9477232 0.83 PLK1 (0.46) NPC1RAB9AALDH1A1LMNAPOLB
SCHEMBL9478131 0.81 PPARA (0.50) ALDH1A1PIN1POLBPPARAPPARG
SCHEMBL21501175 0.81 NPC1 (0.52) NPC1RAB9AHPGDCRHBPCRHR2
SCHEMBL7756224 0.81 NPC1 (0.52) NPC1RAB9AHPGDCRHBPCRHR2
SCHEMBL9475474 0.80 MAPT (0.43) NPC1RAB9AALDH1A1SMN1; SMN2LMNA
SCHEMBL7756146 0.77 NPC1 (0.49) NPC1RAB9AHPGDCRHBPCRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5243066-A ALKYL 2-ARYL-2,2-DIALKOXYACETATES, THE PREPARATION THEREOF AND A METHOD OF USING THEM FOR PREPARING ARYLGLYOXYLIC ESTERS BASF AKTIENGESELLSCHAFT (DE) 1993-09-07 US disclosed