SCHEMBL9475693

SCHEMBL9475693

CCCOc1ccc(-c2ccc(CC/C=C/F)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
ACACB O00763 2/20 0.43
CYP3A4 P08684 3/20 0.41
CYP2D6 P10635 2/20 0.41
SMN1; SMN2 Q16637 4/20 0.41
NPC1 O15118 3/20 0.41
RAB9A P51151 3/20 0.41
KDM4E B2RXH2 2/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
ALDH1A1 P00352 2/20 0.40
USP2 O75604 1/20 0.40
MAPK1 P28482 1/20 0.40
CASP1 P29466 1/20 0.40
SLCO1B3 Q9NPD5 1/20 0.40
SLCO1B1 Q9Y6L6 1/20 0.40
MAPT P10636 1/20 0.40
NFKB1 P19838 1/20 0.40
NFKB2 Q00653 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9475703 1.00 LMNA (0.48) LMNAL3MBTL1ACACBCYP3A4CYP2D6
SCHEMBL9476765 0.94 CYP3A4 (0.49) LMNACYP3A4CYP2D6SMN1; SMN2MEN1
SCHEMBL9476777 0.94 CYP3A4 (0.49) LMNACYP3A4CYP2D6SMN1; SMN2MEN1
SCHEMBL9476546 0.91 CYP3A4 (0.48) LMNACYP3A4CYP2D6SMN1; SMN2NPC1
SCHEMBL9476540 0.91 CYP3A4 (0.48) LMNACYP3A4CYP2D6SMN1; SMN2NPC1
SCHEMBL9477104 0.90 CYP3A4 (0.50) LMNACYP3A4CYP2D6SMN1; SMN2NPC1
SCHEMBL9477114 0.90 CYP3A4 (0.50) LMNACYP3A4CYP2D6SMN1; SMN2NPC1
SCHEMBL9477453 0.88 NQO1 (0.45) L3MBTL1ACACBSMN1; SMN2NPC1RAB9A
SCHEMBL9477467 0.88 NQO1 (0.45) L3MBTL1ACACBSMN1; SMN2NPC1RAB9A
SCHEMBL9479529 0.84 CYP3A4 (0.44) LMNAL3MBTL1ACACBCYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0377469-B1 A LIQUID CRYSTALLINE COMPOUND CHISSO CORPORATION (JP) 1993-10-06 EP disclosed
US-5183587-A LIQUID CRYSTALLINE COMPOUND CHISSO CORPORATION (JP) 1993-02-02 US disclosed
EP-0377469-A1 A liquid crystalline compound CHISSO CORPORATION (JP) 1990-07-11 EP disclosed