Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 5/20 | 0.54 |
| ▸ | CACNA1D | Q01668 | 5/20 | 0.54 |
| ▸ | CACNA1S | Q13698 | 5/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9477546 | 0.91 | CACNA1C (0.44) | CACNA1FCACNA1DCACNA1SCACNA1CTP53 | |
| SCHEMBL9474870 | 0.80 | CACNA1C (0.65) | CACNA1FCACNA1DCACNA1SCACNA1CTP53 | |
| SCHEMBL7384493 | 0.80 | CACNA1C (0.65) | CACNA1FCACNA1DCACNA1SCACNA1CTP53 | |
| SCHEMBL7265838 | 0.75 | CACNA1F (0.54) | CACNA1FCACNA1DCACNA1SCACNA1CTP53 | |
| SCHEMBL9477087 | 0.75 | CACNA1F (0.56) | CACNA1FCACNA1DCACNA1SCACNA1CHTT | |
| SCHEMBL10359264 | 0.74 | CACNA1C (0.50) | CACNA1FCACNA1DCACNA1SCACNA1CHTT | |
| SCHEMBL9476150 | 0.72 | CACNA1C (0.53) | CACNA1FCACNA1DCACNA1SCACNA1CTP53 | |
| SCHEMBL7265684 | 0.70 | CACNA1C (0.51) | CACNA1FCACNA1DCACNA1SCACNA1CTP53 | |
| SCHEMBL7266696 | 0.69 | CACNA1F (0.56) | CACNA1FCACNA1DCACNA1SCACNA1CTP53 | |
| SCHEMBL10359332 | 0.69 | CACNA1F (0.46) | CACNA1FCACNA1DCACNA1SCACNA1CL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202330-A | Hypotensive and cardiovascular agent, reduces blood pressure in mammals | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0204317-A2 | 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1986-12-10 | — | — | EP | disclosed |