Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 3/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.50 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.50 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10359259 | 0.90 | CACNA1C (0.43) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL9474870 | 0.77 | CACNA1C (0.65) | CACNA1CCACNA1FCACNA1DCACNA1SHTT | |
| SCHEMBL7384493 | 0.77 | CACNA1C (0.65) | CACNA1CCACNA1FCACNA1DCACNA1SHTT | |
| SCHEMBL9475776 | 0.74 | CACNA1F (0.54) | CACNA1CCACNA1FCACNA1DCACNA1SHTT | |
| SCHEMBL7265838 | 0.72 | CACNA1F (0.54) | CACNA1CCACNA1FCACNA1DCACNA1SHTT | |
| SCHEMBL10359332 | 0.71 | CACNA1F (0.46) | CACNA1CCACNA1FCACNA1DCACNA1SL3MBTL1 | |
| SCHEMBL9476150 | 0.70 | CACNA1C (0.53) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL10913257 | 0.70 | CACNA1F (0.51) | CACNA1CCACNA1FCACNA1DCACNA1SL3MBTL1 | |
| SCHEMBL9870929 | 0.70 | CACNA1F (0.40) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL7265684 | 0.69 | CACNA1C (0.51) | CACNA1CCACNA1FCACNA1DCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0236902-B1 | 1,2,3,4-TETRAHYDRO-6-SUBSTITUTED-4-ARYL(OR HETEROCYCLO)-3-SUBSTITUTED-2-THIOXO (OR OXO)-5-PYRIMIDINECARBOXYLIC ACIDS AND ESTERS | E.R. Squibb & Sons, Inc. (US) | 1990-12-05 | — | — | EP | disclosed |
| EP-0236902-A1 | 1,2,3,4-tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-substituted-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1987-09-16 | — | — | EP | disclosed |
| US-4684655-A | 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-substituted-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and use thereof to lower blood pressure | E. R. SQUIBB & SONS, INC. (US) | 1987-08-04 | — | — | US | disclosed |