Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLO1 | Q04760 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9476020 | 1.00 | GLO1 (0.50) | GLO1HTTALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7441737 | 0.91 | NPC1 (0.49) | GLO1HTTALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL30938425 | 0.83 | KDM4E (0.55) | GLO1HTTALDH1A1MAPTGAA | |
| SCHEMBL7551989 | 0.83 | KDM4E (0.55) | GLO1HTTALDH1A1MAPTGAA | |
| SCHEMBL31634782 | 0.83 | KDM4E (0.55) | GLO1HTTALDH1A1MAPTGAA | |
| SCHEMBL820380 | 0.82 | AKR1C3 (0.66) | HTTALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7824296 | 0.82 | AKR1C3 (0.66) | HTTALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL9476285 | 0.81 | AKR1C3 (0.51) | GLO1HTTALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9476279 | 0.81 | AKR1C3 (0.51) | GLO1HTTALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8440119 | 0.81 | HTT (0.67) | HTTALDH1A1MAPTSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202330-A | Hypotensive and cardiovascular agent, reduces blood pressure in mammals | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |
| US-4728652-A | VASODILATORS | E. R. SQUIBB & SONS, INC. (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0204317-A2 | 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1986-12-10 | — | — | EP | disclosed |
| EP-0202654-A2 | 5-Carboxy-1,4-dihydropyrimidine derivatives | E.R. Squibb & Sons, Inc. (US) | 1986-11-26 | — | — | EP | disclosed |