Butaprost

Butaprost

SCHEMBL94764

CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGIR P43119 5/20 1.00
PTGER2 P43116 3/20 1.00
LMNA P02545 2/20 0.61
ABCC4 O15439 2/20 0.61
ALDH1A1 P00352 1/20 0.61
PGR P06401 1/20 0.61
POLB P06746 1/20 0.61
MAPT P10636 1/20 0.61
NPSR1 Q6W5P4 1/20 0.61
ABCB11 O95342 1/20 0.61
TSHR P16473 2/20 0.47
PTGER4 P35408 1/20 0.47
MEN1 O00255 1/20 0.47
CYP3A4 P08684 1/20 0.47
HPGD P15428 1/20 0.47
MAPK1 P28482 1/20 0.47
KMT2A Q03164 1/20 0.47
ABCC3 O15438 1/20 0.47
RARB P10826 1/20 0.47
RARG P13631 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butaprost SCHEMBL16335459 1.00 PTGIR (1.00) PTGIRPTGER2LMNAABCC4ALDH1A1
Butaprost SCHEMBL10672693 1.00 PTGIR (1.00) PTGIRPTGER2LMNAABCC4ALDH1A1
SCHEMBL14273618 0.90 PTGIR (1.00) PTGIRPTGER2LMNAABCC4TSHR
SCHEMBL13951097 0.90 PTGIR (1.00) PTGIRPTGER2LMNAABCC4TSHR
SCHEMBL13143656 0.90 PTGIR (1.00) PTGIRPTGER2LMNAABCC4TSHR
SCHEMBL13179799 0.90 PTGIR (1.00) PTGIRPTGER2LMNAABCC4TSHR
SCHEMBL7587667 0.89 PTGIR (0.84) PTGIRPTGER2LMNAABCC4ALDH1A1
SCHEMBL14366538 0.89 PTGIR (0.84) PTGIRPTGER2LMNAABCC4ALDH1A1
SCHEMBL7586539 0.88 PTGIR (0.79) PTGIRPTGER2PGRTSHRPTGER4
SCHEMBL13179800 0.88 PTGIR (0.78) PTGIRPTGER2LMNAABCC4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1261 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250339520-A1 COMPOSITIONS AND METHODS FOR USE IN KRAS-TARGETED THERAPIES FOR THE TREATMENT OF CANCER RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2025-11-06 US claimed
EP-4608405-A1 COMPOSITIONS AND METHODS OF USE FOR MODIFIED RELEASE MINOXIDIL Veradermics, Incorporated (US) 2025-09-03 EP claimed
CN-118453877-A Application of small molecular compound combination in preparing medicine for starting liver in-situ regeneration 中国人民解放军海军军医大学 2024-08-09 CN claimed
WO-2024091572-A1 COMPOSITIONS AND METHODS OF USE FOR MODIFIED RELEASE MINOXIDIL VERADERMICS INCORPORATED (US) 2024-05-02 WO claimed
US-20230404988-A1 PROSTAGLANDIN RECEPTOR AGONISTS FOR USE IN THE TREATMENT OF A CORONAVIRUS INFECTION SUCH AS COVID-19 MEDETIA (FR) 2023-12-21 US claimed
CN-117018195-A Application of small molecular compound or combination in preparation of medicine for starting liver in-situ regeneration 中国人民解放军海军军医大学 2023-11-10 CN claimed
EP-4225319-A1 PROSTAGLANDIN RECEPTOR AGONISTS FOR USE IN THE TREATMENT OF A CORONAVIRUS INFECTION SUCH AS COVID-19 Medetia (FR) 2023-08-16 EP claimed
CN-112661836-B Purification method of buminuo peptide 江苏诺泰澳赛诺生物制药股份有限公司 2023-04-07 CN claimed
US-20220401487-A1 COMPOSITIONS AND METHODS FOR IMMUNE CELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES FATE THERAPEUTICS, INC. 2022-12-22 US claimed
US-11413309-B2 Compositions and methods for immune cell modulation in adoptive immunotherapies FATE THERAPEUTICS, INC. (US) 2022-08-16 US claimed
EP-1385550-A2 THERAPEUTIC METHOD FOR INDUCING TOLERANCE Medical Research Council (GB) 2004-02-04 EP claimed
WO-2003094957-A2 METHODS OF THERAPY FOR INDUCING TOLERANCE MEDICAL RESEARCH COUNCIL (GB) 2003-11-20 WO claimed
WO-2003090699-A1 COSMETIC COMPOSITION FOR PROMOTING HAIR GROWTH AND/OR PREVENTING OR DELAYING HAIR LOSS L'OREAL (FR) 2003-11-06 WO claimed
EP-1358868-A2 Cosmetic composition for increasing hair growth and/or for preventing or delaying hair loss L'OREAL (FR) 2003-11-05 EP claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
WO-2002092097-A1 COMPOSITION COMPRISING PHOSPHODIESTERASE INHIBITORS FOR INDUCING CERVICAL RIPENING MEDICAL RESEARCH COUNCIL (GB) 2002-11-21 WO claimed
WO-2002092064-A2 THERAPEUTIC METHOD FOR INDUCING TOLERANCE MEDICAL RESEARCH COUNCIL (GB) 2002-11-21 WO claimed
WO-1996008254-A1 USE OF BUTAPROST IN PRE-TERM LABOUR BRITISH TECHNOLOGY GROUP LIMITED (GB) 1996-03-21 WO claimed
US-4742080-A Therapeutic method for producing bronchodilation by administration of 15-deoxy-16-hydroxy prostaglandin esters MILES LABORATORIES, INC. (US) 1988-05-03 US claimed
US-4275224-A BRONCHODIALATORS AND ANTI-GASTRIC SECRETION AGENTS MILES LABORATORIES, INC. (US) 1981-06-23 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230404988-A1 PROSTAGLANDIN RECEPTOR AGONISTS FOR USE IN THE TREATMENT OF A CORONAVIRUS INFECTION SUCH AS COVID-19 PTGER4, PTGER2, PTGER1 PTGIR 4/4885PTGER2 2/4885LMNA 3524/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.