Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 8/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9639284 | 1.00 | PRCP (0.59) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL9477025 | 1.00 | PRCP (0.59) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL31513971 | 0.84 | PRCP (0.50) | PRCPGAASLC22A1RECQL | |
| SCHEMBL31137587 | 0.84 | PRCP (0.50) | PRCPGAASLC22A1RECQL | |
| SCHEMBL11638682 | 0.78 | PRCP (0.46) | PRCP | |
| SCHEMBL24017043 | 0.78 | PRCP (0.70) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL30368634 | 0.78 | PRCP (0.70) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL16799768 | 0.78 | PRCP (0.70) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL3865487 | 0.76 | PRCP (0.97) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL28083503 | 0.76 | PRCP (0.90) | PRCPGAASLC22A1RECQLTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5210088-A | Treating pain with tetrahydroisoquinoline derivatives | JOHN WYETH & BROTHER, LIMITED (GB) | 1993-05-11 | — | — | US | claimed |
| US-5118690-A | PHARMACEUTICAL TETRAHYDROISOQUINOLINES | JOHN WYETH & BROTHER LIMITED (GB) | 1992-06-02 | — | — | US | claimed |
| EP-0419247-A2 | Selective GABA antagonists, especially isoquinoline derivatives, and their use for treating CNS disorders | JOHN WYETH & BROTHER LIMITED (GB) | 1991-03-27 | — | — | EP | claimed |
| US-5210088-A | Treating pain with tetrahydroisoquinoline derivatives | JOHN WYETH & BROTHER, LIMITED (GB) | 1993-05-11 | — | — | US | disclosed |
| US-5118690-A | PHARMACEUTICAL TETRAHYDROISOQUINOLINES | JOHN WYETH & BROTHER LIMITED (GB) | 1992-06-02 | — | — | US | disclosed |
| EP-0419247-A2 | Selective GABA antagonists, especially isoquinoline derivatives, and their use for treating CNS disorders | JOHN WYETH & BROTHER LIMITED (GB) | 1991-03-27 | — | — | EP | disclosed |