Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9476484 | 0.84 | GRM2 (0.53) | HTTALDH1A1HPGDTSHRPOLB | |
| SCHEMBL9477531 | 0.83 | NPSR1 (0.53) | HTTALDH1A1HPGDTSHRADORA3 | |
| SCHEMBL9476155 | 0.83 | KDM4E (0.52) | HTTL3MBTL1ALDH1A1HPGDTSHR | |
| SCHEMBL4922738 | 0.82 | ALDH1A1 (0.64) | HTTALDH1A1HPGDTSHRNPSR1 | |
| SCHEMBL9476195 | 0.77 | ADORA3 (0.51) | HTTL3MBTL1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL9476208 | 0.77 | HTT (0.58) | HTTALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL9476832 | 0.75 | HSD17B10 (0.57) | ALDH1A1HPGDTSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL21138864 | 0.71 | AKR1C3 (0.55) | HTTALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL4928309 | 0.71 | ALDH1A1 (0.52) | HTTALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL9475889 | 0.71 | ALDH1A1 (0.61) | HTTALDH1A1HPGDTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204353-A | 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith | CIBA-GEIGY CORPORATION (US) | 1993-04-20 | — | — | US | disclosed |
| EP-0288431-B1 | 3H-1,2,3-triazolo[4,5-d]pyrimidines | CIBA-GEIGY AG (CH) | 1992-08-19 | — | — | EP | disclosed |
| EP-0288431-A1 | 3H-1,2,3-triazolo[4,5-d]pyrimidines | CIBA-GEIGY AG (CH) | 1988-10-26 | — | — | EP | disclosed |