SCHEMBL9479596

SCHEMBL9479596

[c]1cccc(SCCc2ccccc2)n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.43
CYP2D6 P10635 4/20 0.43
CYP2C19 P33261 4/20 0.43
CYP3A4 P08684 3/20 0.43
CYP2C9 P11712 3/20 0.43
HIF1A Q16665 1/20 0.43
AR P10275 1/20 0.38
MAOA P21397 2/20 0.38
MAOB P27338 2/20 0.38
RAB9A P51151 4/20 0.37
NPC1 O15118 3/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
ABCB1 P08183 1/20 0.37
DAO P14920 1/20 0.37
ALDH1A1 P00352 1/20 0.37
USP2 O75604 1/20 0.36
MAPT P10636 1/20 0.36
ALOX15 P16050 1/20 0.36
TSHR P16473 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9480789 0.84 HSD17B10 (0.44) CYP1A2CYP3A4HIF1ARAB9ANPC1
SCHEMBL3182706 0.73 ALDH1A1 (0.62) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL1202201 0.72 KCNH2 (0.55) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL11102244 0.69 CYP1A2 (0.41) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL445016 0.67 NPC1 (0.42) MAOAMAOBRAB9ANPC1SMN1; SMN2
SCHEMBL13752161 0.66 ABCB1 (0.62) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL4612754 0.66 MAOA (0.59) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL223719 0.65 CYP1A2 (0.76) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL8621794 0.64 CYP1A2 (0.43) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL2199347 0.64 CYP1A2 (0.43) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0247381-B1 5-FLUROROURACIL DERIVATIVES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1993-08-04 EP disclosed
US-5047521-A Anticarcinogenic agents OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1991-09-10 US disclosed
EP-0247381-A2 5-flurorouracil derivatives OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1987-12-02 EP disclosed