Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 13/20 | 0.49 |
| ▸ | HRH1 | P35367 | 13/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9471731 | 0.95 | LTA4H (0.63) | LTA4HKCNH2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9472074 | 0.87 | LTA4H (0.53) | LTA4HKCNH2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9471507 | 0.84 | DRD3 (0.61) | LTA4H | |
| SCHEMBL9470806 | 0.82 | MAPT (0.53) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| Hydrochloric Acid SCHEMBL9077228 | 0.81 | KCNH2 (0.56) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9444320 | 0.81 | KCNH2 (0.66) | LTA4HKCNH2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9091140 | 0.80 | KCNH2 (0.52) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9444383 | 0.80 | KCNH2 (0.64) | LTA4HKCNH2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9472050 | 0.80 | LTA4H (0.68) | LTA4HKCNH2HRH3KDM1A | |
| SCHEMBL9472066 | 0.79 | ADRB1 (0.53) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5254689-A | Antiarrhythmia agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-19 | — | — | US | disclosed |
| US-5202346-A | Antiarrhythmic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-13 | — | — | US | disclosed |