SCHEMBL8746509

SCHEMBL8746509

CC1c2ccccc2CCc2ccccc21

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 3/20 0.52
RET P07949 1/20 0.52
HTR2C P28335 2/20 0.50
HTR2B P41595 1/20 0.50
PDPK1 O15530 1/20 0.48
ACP3 P15309 1/20 0.48
PRCP P42785 3/20 0.45
IDO1 P14902 2/20 0.43
CHRM1 P11229 1/20 0.43
DRD2 P14416 1/20 0.43
ADRA2B P18089 1/20 0.43
ADRA2C P18825 1/20 0.43
CHRM3 P20309 1/20 0.43
ADRA1A P35348 1/20 0.43
HRH1 P35367 1/20 0.43
DRD3 P35462 1/20 0.43
KCNH2 Q12809 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL948086 0.84 ACP3 (0.46) HTR2ARETHTR2CHTR2BPDPK1
SCHEMBL9633656 0.84 HTR2A (0.58) HTR2AHTR2CHRH1
SCHEMBL14555196 0.84 HTR2A (0.52) HTR2ARETHTR2CHTR2BPDPK1
SCHEMBL21311775 0.82 CYP2A6 (0.44) HTR2ARETHTR2CHTR2BPDPK1
SCHEMBL16385863 0.80 DRD1 (0.64) HTR2AHTR2CHTR2BDRD2DRD3
SCHEMBL2600798 0.78 HTR2A (0.37) HTR2AHTR2CHTR2BPDPK1PRCP
SCHEMBL20123832 0.78 HTR2C (0.49) HTR2ARETHTR2CHTR2BPDPK1
SCHEMBL22193900 0.78 HTR2A (0.39) HTR2ARETHTR2CHTR2BPDPK1
SCHEMBL8355428 0.78 HTR2A (0.39) HTR2ARETHTR2CHTR2BPDPK1
SCHEMBL19997052 0.78 HTR2A (0.56) HTR2ARETPDPK1ACP3PRCP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3712128-A1 PHOTOCHEMICAL INTERMOLECULAR AMINATION METHOD Fundació Institut Català d'Investigació Química (ICIQ) (ES) 2020-09-23 EP disclosed
EP-3030566-B1 7,8-DIHYDRO-3H-PYRAZINO[1,2-B]PYRIDAZINE-3,5(6H)-DIONE COMPOUNDS AND USES THEREOF JANSSEN BIOPHARMA INC (US) 2020-07-08 EP disclosed
WO-2019052565-A1 INFLUENZA VIRUS REPLICATION INHIBITOR AND USE THEREOF 广东东阳光药业有限公司 2019-03-21 WO disclosed
WO-2017072341-A1 PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE F. HOFFMANN-LA ROCHE AG (CH) 2017-05-04 WO disclosed
EP-0485431-B1 PARTIAL AGONISTS OF THE STRYCHNINE INSENSITIVE GLYCINE MODULATORY SITE OF THE N-METHYL-D-ASPARTATE RECEPTOR COMPLEX AS NEUROPSYCHOPHARMACOLOGICAL AGENTS US HEALTH (US) 1997-02-19 EP disclosed
WO-1991001729-A1 PARTIAL AGONISTS OF THE STRYCHNINE INSENSITIVE GLYCINE MODULATORY SITE OF THE N-METHYL-D-ASPARTATE RECEPTOR COMPLEX AS NEUROPSYCHOPHARMACOLOGICAL AGENTS THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, U.S. DEPARTMENT OF COMMERCE (US) 1991-02-21 WO disclosed