Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | CES2 | O00748 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7525758 | 0.90 | EP300 (0.43) | EP300ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL5831940 | 0.83 | EP300 (0.43) | EP300ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL5831471 | 0.79 | EP300 (0.39) | EP300ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL5831498 | 0.77 | EP300 (0.43) | EP300ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL7844009 | 0.75 | EP300 (0.66) | EP300ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18254504 | 0.74 | EP300 (0.49) | EP300ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL17717907 | 0.73 | EP300 (0.48) | EP300ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL17717901 | 0.72 | EP300 (0.50) | EP300ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL15978110 | 0.72 | MMP1 (0.52) | EP300ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL15978133 | 0.72 | EP300 (0.47) | EP300ALDH1A1MAPTHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526537-A1 | 5-BENZYL BARBITURATE DERIVATIVES. | UNIV BROWN RES FOUND (US) | 1993-02-10 | — | — | EP | claimed |
| WO-1991016315-A1 | 5-BENZYL BARBITURATE DERIVATIVES | BROWN UNIVERSITY RESEARCH FOUNDATION (US) | 1991-10-31 | — | — | WO | claimed |