Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.42 |
| ▸ | RXRB | P28702 | 5/20 | 0.42 |
| ▸ | RARB | P10826 | 11/20 | 0.40 |
| ▸ | RARG | P13631 | 11/20 | 0.40 |
| ▸ | RARA | P10276 | 8/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.40 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 3/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9320778 | 0.80 | RXRA (0.35) | RXRARARBRARGRARACYP26A1 | |
| SCHEMBL7931062 | 0.80 | RXRA (0.40) | RXRARXRBRARBRARGRARA | |
| SCHEMBL7929330 | 0.80 | RARB (0.38) | RXRARXRBRARBRARGRARA | |
| SCHEMBL7929331 | 0.80 | RARB (0.38) | RXRARXRBRARBRARGRARA | |
| SCHEMBL2223445 | 0.79 | RARB (0.53) | RXRARXRBRARBRARGRARA | |
| SCHEMBL9483828 | 0.76 | RARB (0.63) | RXRARXRBRARBRARGRARA | |
| SCHEMBL11240964 | 0.74 | RXRA (0.54) | RXRARXRBRARBRARGRARA | |
| SCHEMBL10515701 | 0.73 | RARB (0.58) | RXRARXRBRARBRARGRARA | |
| SCHEMBL10515704 | 0.73 | RARB (0.58) | RXRARXRBRARBRARGRARA | |
| SCHEMBL3175854 | 0.70 | RXRA (0.57) | RXRARXRBRARBRARGRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5256694-A | For skin disorders; carcinomas | BASF AKTIENGESELLSCHAFT (DE) | 1993-10-26 | — | — | US | disclosed |
| US-5126371-A | Precancerous skin conditions, acne, psoriasis | BASF AKTEINGESELLSCHAFT (DE) | 1992-06-30 | — | — | US | disclosed |
| US-4994489-A | Ester derivatives of diarylacetylenes, their compositions and their use in acne treatment | BASF AKTIENGESELLSCHAFT | 1991-02-19 | — | — | US | disclosed |
| EP-0176034-B1 | DIARYL ACETYLENES, THEIR PREPARATION AND USE | BASF Aktiengesellschaft (DE) | 1989-08-30 | — | — | EP | disclosed |
| US-4806558-A | Diarylacetylenes and their use in treating acne | BASF AKTIENGESELLSCHAFT (DE) | 1989-02-21 | — | — | US | disclosed |
| EP-0176034-A2 | Diaryl acetylenes, their preparation and use | BASF Aktiengesellschaft (DE) | 1986-04-02 | — | — | EP | disclosed |