Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9484539 | 0.75 | RARB (0.38) | BACE1BACE2 | |
| SCHEMBL6477078 | 0.73 | CYP26A1 (0.33) | BACE1CTSDBACE2 | |
| SCHEMBL9483415 | 0.72 | RARB (0.38) | RXRA | |
| SCHEMBL1468020 | 0.71 | RXRA (0.39) | RXRA | |
| SCHEMBL29870908 | 0.71 | RXRA (0.39) | RXRA | |
| SCHEMBL9484220 | 0.71 | RARB (0.41) | RXRABACE1CTSDBACE2 | |
| SCHEMBL2223568 | 0.71 | RARB (0.53) | RXRA | |
| SCHEMBL10335841 | 0.69 | ADRA2A (0.35) | RXRABACE1CTSDBACE2 | |
| SCHEMBL15309162 | 0.69 | HDAC8 (0.32) | — | |
| SCHEMBL5594371 | 0.69 | CYP26A1 (0.31) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5256694-A | For skin disorders; carcinomas | BASF AKTIENGESELLSCHAFT (DE) | 1993-10-26 | — | — | US | disclosed |
| US-5126371-A | Precancerous skin conditions, acne, psoriasis | BASF AKTEINGESELLSCHAFT (DE) | 1992-06-30 | — | — | US | disclosed |
| US-4994489-A | Ester derivatives of diarylacetylenes, their compositions and their use in acne treatment | BASF AKTIENGESELLSCHAFT | 1991-02-19 | — | — | US | disclosed |
| US-4806558-A | Diarylacetylenes and their use in treating acne | BASF AKTIENGESELLSCHAFT (DE) | 1989-02-21 | — | — | US | disclosed |