Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.68 |
| ▸ | PDE3B | Q13370 | 12/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.53 |
| ▸ | PDE4A | P27815 | 5/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | GALR3 | O60755 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7291472 | 0.94 | HRH3 (0.70) | HRH3PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9484349 | 0.86 | HRH3 (0.70) | HRH3PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7299208 | 0.85 | GPR119 (0.55) | HRH3PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7335052 | 0.83 | HRH3 (0.57) | HRH3PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10369572 | 0.82 | HRH3 (0.59) | HRH3PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10353457 | 0.82 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL1376025 | 0.81 | HRH3 (1.00) | HRH3PDE3BPDE3APDE4APDE4B | |
| SCHEMBL13119591 | 0.81 | HRH3 (0.90) | HRH3PDE3BPDE3AKCNH2GPR119 | |
| SCHEMBL7327130 | 0.81 | HRH3 (0.60) | HRH3PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7325184 | 0.81 | HRH3 (0.53) | HRH3PDE3BPDE3APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |