Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 11/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1081985 | 0.91 | S1PR1 (0.44) | S1PR1S1PR4S1PR5ABCG2TP53 | |
| Hydrochloric Acid SCHEMBL946955 | 0.83 | S1PR1 (0.49) | S1PR1S1PR4S1PR5MAPKAPK2S1PR3 | |
| SCHEMBL2567415 | 0.81 | S1PR1 (0.70) | S1PR1S1PR4S1PR5 | |
| SCHEMBL946049 | 0.80 | S1PR1 (0.56) | S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL945433 | 0.80 | S1PR1 (0.62) | S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL948216 | 0.80 | S1PR1 (0.69) | S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL2563713 | 0.79 | S1PR1 (0.58) | S1PR1S1PR4S1PR5MAPTSMN1; SMN2 | |
| SCHEMBL946662 | 0.78 | S1PR1 (0.58) | S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL949021 | 0.75 | KIF11 (0.47) | ABCG2MAPKAPK2TP53MAPTABCB1 | |
| SCHEMBL947568 | 0.74 | TRPV1 (0.49) | MAPKAPK2TP53MAPTSIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |