Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL283212 | 0.94 | MAPK1 (0.60) | HTTMAPK1TDP1L3MBTL1CYP2C9 | |
| SCHEMBL5711116 | 0.91 | SLC22A12 (0.67) | HTTMAPK1TDP1L3MBTL1CYP2C9 | |
| SCHEMBL9486589 | 0.88 | HTT (0.60) | HTTMAPK1TDP1L3MBTL1CYP2C9 | |
| SCHEMBL4567254 | 0.85 | KDM5A (0.58) | — | |
| SCHEMBL27820229 | 0.85 | MAPK1 (0.51) | HTTMAPK1TDP1L3MBTL1EYA3 | |
| SCHEMBL30140853 | 0.85 | MAPK1 (0.51) | HTTMAPK1TDP1L3MBTL1EYA3 | |
| SCHEMBL12643780 | 0.85 | MAPK1 (0.51) | HTTMAPK1TDP1L3MBTL1EYA3 | |
| SCHEMBL422204 | 0.84 | SLC22A12 (0.54) | HTTMAPK1TDP1L3MBTL1CYP2C9 | |
| SCHEMBL9486866 | 0.84 | ESR1 (0.63) | — | |
| SCHEMBL9486597 | 0.83 | HTT (0.87) | HTTMAPK1TDP1L3MBTL1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5223510-A | ALKYLAMINOALKYL DERIVATIVES OF BENZOFURAN, BENZOTHIOPHENE, INDOLE AND INDOLIZINE, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | SANOFI (FR) | 1993-06-29 | — | — | US | disclosed |