Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9487491 | 1.00 | ALDH1A1 (0.49) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL10875341 | 0.98 | ALDH1A1 (0.50) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL9486433 | 0.81 | ALDH1A1 (0.51) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL9487852 | 0.81 | ALDH1A1 (0.51) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL9486428 | 0.81 | ALDH1A1 (0.51) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL9487845 | 0.81 | ALDH1A1 (0.51) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL17200771 | 0.79 | ALDH1A1 (0.49) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL15752277 | 0.79 | ALDH1A1 (0.49) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL9487501 | 0.78 | ALDH1A1 (0.48) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL10414880 | 0.78 | ALDH1A1 (0.48) | ALDH1A1MAPTKDM4EHPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5206375-A | Thiophene derivatives | BASF AKTIENGESELLSCHAFT (DE) | 1993-04-27 | — | — | US | disclosed |