SCHEMBL9488180

SCHEMBL9488180

Cc1cccc(Sc2c(C)ccc(C)c2C)c1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.42
HTR1A P08908 4/20 0.42
HTR3A P46098 4/20 0.42
CYP3A4 P08684 2/20 0.42
CYP2D6 P10635 2/20 0.42
CYP2C9 P11712 2/20 0.42
TRPA1 O75762 1/20 0.38
ATM Q13315 1/20 0.38
NOTUM Q6P988 1/20 0.38
CYP2A6 P11509 2/20 0.33
SCN4A P35499 3/20 0.32
TSHR P16473 3/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA7 P43166 1/20 0.32
CA9 Q16790 1/20 0.32
ALDH1A1 P00352 1/20 0.32
ACHE P22303 1/20 0.32
NPC1 O15118 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9488037 0.91 HTR1A (0.45) CYP1A2HTR1AHTR3ACYP3A4CYP2D6
SCHEMBL9486797 0.87 HAO1 (0.42) CYP1A2HTR1AHTR3ACYP3A4CYP2D6
SCHEMBL9487225 0.84 TRPA1 (0.42) CYP1A2TRPA1ATMCYP2A6SCN4A
SCHEMBL576045 0.84 HTR1A (0.53) CYP1A2HTR1AHTR3ACYP3A4CYP2D6
SCHEMBL29589002 0.84 HTR1A (0.53) CYP1A2HTR1AHTR3ACYP3A4CYP2D6
SCHEMBL29687933 0.84 HTR1A (0.53) CYP1A2HTR1AHTR3ACYP3A4CYP2D6
SCHEMBL29073066 0.79 HTR1A (0.54) CYP1A2HTR1AHTR3ACYP3A4CYP2D6
SCHEMBL2863653 0.79 TRPA1 (0.56) CYP1A2HTR1AHTR3ACYP3A4CYP2D6
SCHEMBL9488937 0.77 HTR1A (0.53) CYP1A2HTR1AHTR3ACYP3A4CYP2D6
SCHEMBL9488226 0.77 HAO1 (0.47) CYP1A2HTR1AHTR3ANOTUMCYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5250657-A Process for preparing polyarylene thioether SEISAN KAIHATSU KAGAKU KENKYUSHO (JP) 1993-10-05 US disclosed
EP-0440106-A2 Process for preparing polyarylene thioethers SEISAN KAIHATSU KAGAKU KENKYUSHO (JP) 1991-08-07 EP disclosed