SCHEMBL9488197

SCHEMBL9488197

COc1ccc(C2(CBr)OCC(CO)O2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.38
MAOA P21397 1/20 0.38
CHRNA1 P02708 1/20 0.36
CHRNG P07510 1/20 0.36
CHRNB1 P11230 1/20 0.36
CHRNB2 P17787 1/20 0.36
CHRNB4 P30926 1/20 0.36
CHRNA3 P32297 1/20 0.36
CHRNA4 P43681 1/20 0.36
CHRND Q07001 1/20 0.36
SLC5A1 P13866 2/20 0.34
SLC5A2 P31639 2/20 0.34
HSD11B1 P28845 1/20 0.33
GSK3B P49841 1/20 0.33
HSP90AA1 P07900 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
ADRA1A P35348 1/20 0.32
ADRA1B P35368 1/20 0.32
SLC6A4 P31645 2/20 0.32
SLC6A3 Q01959 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12132813 0.86 MAOB (0.38) MAOBMAOACHRNA1CHRNGCHRNB1
SCHEMBL12132814 0.86 MAOB (0.38) MAOBMAOACHRNA1CHRNGCHRNB1
SCHEMBL10851218 0.85 MAOB (0.37) MAOBMAOACHRNA1CHRNGCHRNB1
SCHEMBL9462482 0.84 MMP9 (0.38) ADRA1AADRA1B
SCHEMBL2285365 0.83 PTGS2 (0.43) MAOBMAOACHRNA1CHRNGCHRNB1
SCHEMBL1352046 0.83 PTGS2 (0.43) MAOBMAOACHRNA1CHRNGCHRNB1
SCHEMBL1350549 0.83 PTGS2 (0.43) MAOBMAOACHRNA1CHRNGCHRNB1
SCHEMBL8322217 0.83 PTGS2 (0.43) MAOBMAOACHRNA1CHRNGCHRNB1
SCHEMBL1350551 0.83 PTGS2 (0.43) MAOBMAOACHRNA1CHRNGCHRNB1
SCHEMBL2285363 0.83 PTGS2 (0.43) MAOBMAOACHRNA1CHRNGCHRNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5236944-A C1-4 alkyl(4-(2-(4-C1-4-alkylphenyl)-2(1H-imidazol-1-ylmethyl) -1,3-dioxolan-4-ylemthlthio)phenyl)carbamate JANSSEN PHARMACEUTICA N.V. (BE) 1993-08-17 US disclosed
EP-0335446-A2 Agents for treating neoplasms JANSSEN PHARMACEUTICA N.V. (BE) 1989-10-04 EP disclosed