Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 5/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | TPMT | P51580 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9488888 | 0.93 | ACACB (0.39) | ACACBROCK2ROCK1MTNR1AMTNR1B | |
| SCHEMBL9488414 | 0.86 | TRPV1 (0.41) | MTNR1AMTNR1BTRPV1ACHEKMT2A | |
| SCHEMBL9488311 | 0.84 | ACACB (0.37) | ACACBROCK2ROCK1TSHR | |
| SCHEMBL9489442 | 0.83 | — | — | |
| SCHEMBL9489374 | 0.83 | MGAM (0.43) | ROCK2ROCK1ACHE | |
| SCHEMBL8536466 | 0.82 | CA12 (0.47) | MTNR1AMTNR1BTRPV1TSHRCA12 | |
| SCHEMBL9373824 | 0.79 | PRSS1 (0.38) | MTNR1AMTNR1BTSHRKMT2A | |
| SCHEMBL9373727 | 0.79 | PPARA (0.41) | MTNR1AMTNR1BTRPV1 | |
| SCHEMBL8533902 | 0.79 | GPR84 (0.46) | MTNR1AMTNR1BTRPV1TSHRKMT2A | |
| SCHEMBL8533040 | 0.79 | GPR84 (0.46) | MTNR1AMTNR1BTRPV1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337766-B1 | HETERA-ALIPHATIC CARBOXAMIDES | ICI AMERICAS INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| US-5041460-A | Antiallergens, antiinflammatory agents and leukotriene antagonists | ICI AMERICAS INC. (US) | 1991-08-20 | — | — | US | disclosed |
| EP-0337766-A1 | Hetera-aliphatic carboxamides | ICI AMERICAS INC. (US) | 1989-10-18 | — | — | EP | disclosed |