Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9428159 | 0.80 | CYSLTR2 (0.47) | ADRB2ADRB1ADRB3FAAHTRPA1 | |
| SCHEMBL9560179 | 0.75 | CYSLTR2 (0.56) | ADRB2ADRB1ADRB3FAAH | |
| SCHEMBL9561206 | 0.74 | FAAH (0.37) | ADRB2ADRB1ADRB3FAAHTRPA1 | |
| SCHEMBL27586622 | 0.71 | MAPT (0.59) | ADRB2ADRB1ADRB3FAAHMAPK1 | |
| SCHEMBL13356917 | 0.70 | MMP2 (0.45) | — | |
| SCHEMBL10578604 | 0.70 | HDAC1 (0.56) | ADRB2ADRB1ADRB3ALDH1A1HPGD | |
| SCHEMBL9196120 | 0.69 | MAPT (0.56) | ADRB2ADRB1ADRB3FAAHMAPK1 | |
| SCHEMBL9485343 | 0.69 | CYSLTR2 (0.49) | — | |
| SCHEMBL5400156 | 0.69 | GRIK1 (0.54) | — | |
| SCHEMBL5400150 | 0.69 | GRIK1 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527175-A4 | 3-NAPHTHYL-3-CARBOXYALKYLTHIO OR OXY SUBSTITUTED ALKANOIC ACID LEUKOTRIENE ANTAGONISTS | — | 1993-05-05 | — | — | EP | disclosed |
| EP-0527175-A1 | 3-NAPHTHYL-3-CARBOXYALKYLTHIO OR OXY SUBSTITUTED ALKANOIC ACID LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-17 | — | — | EP | disclosed |
| WO-1991017149-A1 | 3-NAPHTHYL-3-CARBOXYALKYLTHIO OR OXY SUBSTITUTED ALKANOIC ACID LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-11-14 | — | — | WO | disclosed |