Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9488925 | 1.00 | LMNA (0.44) | LMNACA1CA2CA4CA7 | |
| SCHEMBL9488920 | 1.00 | LMNA (0.44) | LMNACA1CA2CA4CA7 | |
| SCHEMBL476991 | 0.81 | CYP1A2 (0.41) | LMNACA1CA2CA4CA7 | |
| SCHEMBL10436866 | 0.79 | CA1 (0.43) | LMNACA1CA2CA4CA7 | |
| SCHEMBL10436864 | 0.79 | CA1 (0.43) | LMNACA1CA2CA4CA7 | |
| SCHEMBL780327 | 0.78 | PKM (0.48) | LMNAGAAF2PRSS1PRSS2 | |
| SCHEMBL15000836 | 0.77 | LMNA (0.55) | LMNACA1CA2CA9GAA | |
| SCHEMBL6115267 | 0.77 | LMNA (0.55) | LMNACA1CA2CA9GAA | |
| SCHEMBL8091941 | 0.77 | KMT2A (0.43) | LMNAGAAF2MAPTALDH1A1 | |
| SCHEMBL4337229 | 0.76 | TSHR (0.50) | LMNACA1CA2CA4CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5236944-A | C1-4 alkyl(4-(2-(4-C1-4-alkylphenyl)-2(1H-imidazol-1-ylmethyl) -1,3-dioxolan-4-ylemthlthio)phenyl)carbamate | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-08-17 | — | — | US | disclosed |
| EP-0335446-A2 | Agents for treating neoplasms | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-10-04 | — | — | EP | disclosed |