Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.58 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GYS1 | P13807 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9489975 | 0.91 | AKR1B10 (0.58) | AKR1B10AKR1A1AKR1B1CYP2C9CYP1A2 | |
| SCHEMBL9489533 | 0.89 | AKR1B10 (0.67) | AKR1B10AKR1A1AKR1B1CYP2C9CYP1A2 | |
| SCHEMBL9490871 | 0.89 | AKR1B10 (0.59) | AKR1B10AKR1A1AKR1B1GYS1SLC6A9 | |
| SCHEMBL9489106 | 0.88 | AKR1B10 (0.58) | AKR1B10AKR1A1AKR1B1GYS1SLC6A9 | |
| SCHEMBL9489702 | 0.87 | AKR1B10 (0.61) | AKR1B10AKR1A1AKR1B1CYP2C9GYS1 | |
| SCHEMBL9491827 | 0.86 | AKR1B10 (0.48) | AKR1B10AKR1A1AKR1B1CYP2C9CYP1A2 | |
| SCHEMBL9489280 | 0.85 | AKR1B10 (0.59) | AKR1B10AKR1A1AKR1B1GYS1ALDH1A1 | |
| SCHEMBL9491641 | 0.85 | AKR1B10 (0.59) | AKR1B10AKR1A1AKR1B1CYP2C9GYS1 | |
| SCHEMBL9489570 | 0.85 | AKR1B10 (0.59) | AKR1B10AKR1A1AKR1B1GYS1ALDH1A1 | |
| SCHEMBL9491073 | 0.83 | AKR1B10 (0.46) | AKR1B10AKR1A1AKR1B1CYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322255-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| US-4962224-A | TREATMENT OR PREVENTION OF DIABETES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-09 | — | — | US | disclosed |
| EP-0322255-A1 | N-acyl-N-naphthoylglycines as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-28 | — | — | EP | disclosed |