Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.59 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | VDR | P11473 | 1/20 | 0.34 |
| ▸ | GYS1 | P13807 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9489106 | 0.95 | AKR1B10 (0.58) | AKR1B10AKR1A1AKR1B1SLC6A9KEAP1 | |
| SCHEMBL9489975 | 0.91 | AKR1B10 (0.58) | AKR1B10AKR1A1AKR1B1SLC6A9KEAP1 | |
| SCHEMBL9489337 | 0.89 | AKR1B10 (0.58) | AKR1B10AKR1A1AKR1B1KDM4ESLC6A9 | |
| SCHEMBL9489702 | 0.85 | AKR1B10 (0.61) | AKR1B10AKR1A1AKR1B1SLC6A9GYS1 | |
| SCHEMBL9489264 | 0.84 | AKR1B10 (0.47) | AKR1B10AKR1A1AKR1B1KDM4EPDE4D | |
| SCHEMBL9491641 | 0.84 | AKR1B10 (0.59) | AKR1B10AKR1A1AKR1B1SLC6A9GYS1 | |
| SCHEMBL9489280 | 0.84 | AKR1B10 (0.59) | AKR1B10AKR1A1AKR1B1KDM4ESLC6A9 | |
| SCHEMBL9489570 | 0.83 | AKR1B10 (0.59) | AKR1B10AKR1A1AKR1B1KDM4EKEAP1 | |
| SCHEMBL9489565 | 0.81 | AKR1B10 (0.67) | AKR1B10AKR1A1AKR1B1KDM4ESLC6A9 | |
| SCHEMBL10388876 | 0.80 | AKR1B10 (0.51) | AKR1B10AKR1A1AKR1B1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322255-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| US-4962224-A | TREATMENT OR PREVENTION OF DIABETES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-09 | — | — | US | disclosed |
| EP-0322255-A1 | N-acyl-N-naphthoylglycines as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-28 | — | — | EP | disclosed |