Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.40 |
| ▸ | TEK | Q02763 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TAS2R8 | Q9NYW2 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16260552 | 0.84 | CYP19A1 (0.50) | ACACBRAB9AALDH1A1KLKB1KDR | |
| SCHEMBL16343259 | 0.83 | L3MBTL1 (0.57) | ACACBL3MBTL1HSD17B10KLKB1POLB | |
| SCHEMBL15759268 | 0.79 | KLKB1 (0.51) | SMN1; SMN2RAB9AL3MBTL1DUSP3ALDH1A1 | |
| SCHEMBL3593783 | 0.75 | MAPT (0.68) | SMN1; SMN2RAB9AL3MBTL1DUSP3ALDH1A1 | |
| SCHEMBL18802962 | 0.75 | LMNA (0.54) | SMN1; SMN2RAB9AL3MBTL1DUSP3ALDH1A1 | |
| SCHEMBL4769322 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9AL3MBTL1DUSP3ALDH1A1 | |
| SCHEMBL2821950 | 0.73 | HSD17B10 (0.43) | SMN1; SMN2RAB9AL3MBTL1DUSP3ALDH1A1 | |
| SCHEMBL16804397 | 0.73 | CACNA1H (0.43) | SMN1; SMN2RAB9AL3MBTL1DUSP3ALDH1A1 | |
| SCHEMBL948453 | 0.73 | HSD17B10 (0.61) | SMN1; SMN2L3MBTL1ALDH1A1HSD17B10KLKB1 | |
| SCHEMBL949612 | 0.73 | KLKB1 (0.53) | ALDH1A1HSD17B10KLKB1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110021498-A1 | INDOLYL- PYRIDONE DERIVATIVES HAVING CHECKPOINT KINASE 1 INHIBITORY ACTIVITY | VERNALIS (R & D) LTD (GB) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021498-A1 | INDOLYL- PYRIDONE DERIVATIVES HAVING CHECKPOINT KINASE 1 INHIBITORY ACTIVITY | CHEK1, CHEK2, BUB1 | ACACB 1688/4885CYP3A4 2762/4885CYP2C9 2525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.