Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9489469 | 0.91 | AKR1B10 (0.46) | PTGS2AKR1B10AKR1A1AKR1B1KDM4E | |
| SCHEMBL9491854 | 0.90 | PTGS2 (0.40) | PTGS2AKR1B10AKR1A1AKR1B1MEN1 | |
| SCHEMBL9489637 | 0.82 | AKR1B10 (0.43) | PTGS2AKR1B10AKR1A1AKR1B1CYP2C19 | |
| SCHEMBL10641624 | 0.81 | AKR1B10 (0.56) | PTGS2AKR1B10AKR1A1AKR1B1KDM4E | |
| SCHEMBL9490146 | 0.80 | AKR1B10 (0.47) | AKR1B10AKR1A1AKR1B1KDM4EHPGD | |
| SCHEMBL9491061 | 0.80 | AKR1B10 (0.44) | PTGS2AKR1B10AKR1A1AKR1B1PDE4A | |
| SCHEMBL9490521 | 0.79 | AKR1B10 (0.43) | PTGS2AKR1B10AKR1A1AKR1B1KDM4E | |
| SCHEMBL9491210 | 0.75 | AKR1B10 (0.43) | PTGS2AKR1B10AKR1A1AKR1B1CYP2C19 | |
| SCHEMBL10388876 | 0.74 | AKR1B10 (0.51) | PTGS2AKR1B10AKR1A1AKR1B1KDM4E | |
| SCHEMBL10416215 | 0.73 | AKR1B10 (0.61) | AKR1B10AKR1A1AKR1B1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322255-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| US-4962224-A | TREATMENT OR PREVENTION OF DIABETES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-09 | — | — | US | disclosed |
| EP-0322255-A1 | N-acyl-N-naphthoylglycines as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-28 | — | — | EP | disclosed |