Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9490565 | 0.87 | AKR1B10 (0.42) | AKR1B10AKR1A1AKR1B1KMT2AMAPT | |
| SCHEMBL9490331 | 0.78 | AKR1B10 (0.46) | AKR1B10AKR1A1AKR1B1KMT2AMEN1 | |
| SCHEMBL9490610 | 0.77 | AKR1B10 (0.42) | AKR1B10AKR1A1AKR1B1TSHRKMT2A | |
| SCHEMBL9490667 | 0.76 | AKR1B10 (0.46) | AKR1B10AKR1A1AKR1B1TSHRKMT2A | |
| SCHEMBL9490525 | 0.75 | AKR1B10 (0.43) | AKR1B10AKR1A1AKR1B1TSHRMAPT | |
| SCHEMBL9489637 | 0.75 | AKR1B10 (0.43) | AKR1B10AKR1A1AKR1B1KMT2AMEN1 | |
| SCHEMBL9489775 | 0.74 | AKR1B10 (0.43) | AKR1B10AKR1A1AKR1B1KMT2AMAPT | |
| SCHEMBL9491059 | 0.73 | AKR1B10 (0.42) | AKR1B10AKR1A1AKR1B1TSHRKMT2A | |
| SCHEMBL9491641 | 0.72 | AKR1B10 (0.59) | AKR1B10AKR1A1AKR1B1KMT2AMAPT | |
| SCHEMBL9489025 | 0.72 | AKR1B10 (0.48) | AKR1B10AKR1A1AKR1B1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322256-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| WO-1989005793-A1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-29 | — | — | WO | disclosed |
| EP-0322256-A1 | N-acyl-N-naphthoylglycines as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-28 | — | — | EP | disclosed |
| US-4820727-A | TREATING DIABETIC COMPLICATIONS-VISION DEFECTS, KIDNEY AND NERVOUS SYSTEM DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-04-11 | — | — | US | disclosed |