Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9490331 | 0.87 | AKR1B10 (0.46) | AKR1B10AKR1A1AKR1B1L3MBTL1KDM4E | |
| SCHEMBL9490565 | 0.82 | AKR1B10 (0.42) | AKR1B10AKR1A1AKR1B1L3MBTL1HTT | |
| SCHEMBL9491641 | 0.78 | AKR1B10 (0.59) | AKR1B10AKR1A1AKR1B1L3MBTL1POLB | |
| SCHEMBL9490510 | 0.77 | AKR1B10 (0.41) | AKR1B10AKR1A1AKR1B1L3MBTL1KDM4E | |
| SCHEMBL9491074 | 0.76 | AKR1B10 (0.39) | AKR1B10AKR1A1AKR1B1L3MBTL1KDM4E | |
| SCHEMBL10415791 | 0.76 | AKR1B10 (0.60) | AKR1B10AKR1A1AKR1B1KDM4EHTT | |
| SCHEMBL9490146 | 0.75 | AKR1B10 (0.47) | AKR1B10AKR1A1AKR1B1L3MBTL1KDM4E | |
| SCHEMBL9489025 | 0.75 | AKR1B10 (0.48) | AKR1B10AKR1A1AKR1B1L3MBTL1POLB | |
| SCHEMBL9491008 | 0.74 | AKR1B10 (0.41) | AKR1B10AKR1A1AKR1B1L3MBTL1POLB | |
| SCHEMBL2172500 | 0.74 | ERN1 (0.54) | L3MBTL1KDM4EPOLBCTDSP1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322256-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| WO-1989005793-A1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-29 | — | — | WO | disclosed |
| EP-0322256-A1 | N-acyl-N-naphthoylglycines as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-28 | — | — | EP | disclosed |
| US-4820727-A | TREATING DIABETIC COMPLICATIONS-VISION DEFECTS, KIDNEY AND NERVOUS SYSTEM DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-04-11 | — | — | US | disclosed |