Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9489570 | 0.83 | AKR1B10 (0.59) | TTRKDM4EHSD17B10AKR1B10AKR1A1 | |
| SCHEMBL10586917 | 0.83 | KDM4E (0.42) | TTRKDM4EHSD17B10AKR1B10AKR1A1 | |
| SCHEMBL10586920 | 0.83 | AKR1B10 (0.44) | TTRKDM4EHSD17B10AKR1B10AKR1A1 | |
| SCHEMBL9490146 | 0.82 | AKR1B10 (0.47) | KDM4EAKR1B10AKR1A1AKR1B1CA12 | |
| SCHEMBL9489527 | 0.81 | AKR1B10 (0.68) | TTRKDM4EHSD17B10AKR1B10AKR1A1 | |
| SCHEMBL10387875 | 0.81 | MRGPRX4 (0.47) | AKR1B10AKR1A1AKR1B1RAB9ASMN1; SMN2 | |
| SCHEMBL9489060 | 0.80 | AKR1B10 (0.46) | KDM4EAKR1B10AKR1A1AKR1B1CA12 | |
| SCHEMBL9489260 | 0.80 | TSHR (0.47) | KDM4EHSD17B10AKR1B10AKR1A1AKR1B1 | |
| SCHEMBL9489560 | 0.80 | ALDH1A1 (0.47) | TTRKDM4EHSD17B10AKR1B10AKR1A1 | |
| SCHEMBL9490331 | 0.80 | AKR1B10 (0.46) | KDM4EAKR1B10AKR1A1AKR1B1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322255-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| US-4962224-A | TREATMENT OR PREVENTION OF DIABETES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-09 | — | — | US | disclosed |
| EP-0322255-A1 | N-acyl-N-naphthoylglycines as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-28 | — | — | EP | disclosed |