Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TYMP | P19971 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25778574 | 0.88 | KDM4E (0.55) | KDM4EPARP1ALDH1A1TYMPKMT2A | |
| SCHEMBL5935686 | 0.83 | TP53 (0.53) | KMT2AHSD17B10MEN1TSHRHTT | |
| SCHEMBL26688859 | 0.83 | LMNA (0.51) | KDM4EPARP1ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL9487922 | 0.82 | PARP1 (0.51) | KDM4EPARP1ALDH1A1TYMPPKM | |
| SCHEMBL1891525 | 0.79 | TSHR (0.43) | KDM4EPARP1ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL20778195 | 0.79 | MAPK1 (0.63) | KDM4EPARP1ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL30296207 | 0.79 | MAPK1 (0.43) | KDM4EPARP1ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL9126278 | 0.76 | PARP1 (0.49) | KDM4EPARP1ALDH1A1LMNAHIF1A | |
| Dimethirimol SCHEMBL6908351 | 0.75 | KDM4E (0.52) | KDM4EALDH1A1TYMPKMT2AHSD17B10 | |
| SCHEMBL20778200 | 0.74 | KDM4E (0.52) | KDM4EPARP1ALDH1A1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5252574-A | Hypotensive agents, vision disorder | MERCK & CO., INC. (US) | 1993-10-12 | — | — | US | disclosed |
| US-5175164-A | Hypotensive agents | MERCK & CO., INC. (US) | 1992-12-29 | — | — | US | disclosed |
| EP-0517357-A1 | Angiotensin II antagonists incorporating a substituted indole or dihydroindole | MERCK & CO. INC. (US) | 1992-12-09 | — | — | EP | disclosed |
| EP-0512676-A1 | Angiotensin II antagonists incorporating a substituted benzyl element | MERCK & CO. INC. (US) | 1992-11-11 | — | — | EP | disclosed |
| US-5162325-A | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO., INC. (US) | 1992-11-10 | — | — | US | disclosed |
| EP-0510812-A1 | Angiotensin II antagonists incorporating a substituted thiophene or furan | MERCK & CO. INC. (US) | 1992-10-28 | — | — | EP | disclosed |
| US-5100897-A | Hypotensive agents, congestive heart failure, ocular hypertension | MERCK & CO., INC. (US) | 1992-03-31 | — | — | US | disclosed |
| EP-0419048-A2 | Substituted pyrimidinones as angiotensin II antagonists | MERCK & CO. INC. (US) | 1991-03-27 | — | — | EP | disclosed |