Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 15/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945998 | 0.81 | S1PR1 (0.54) | S1PR1S1PR5S1PR4 | |
| SCHEMBL12320295 | 0.78 | S1PR1 (0.54) | S1PR1S1PR5S1PR4 | |
| SCHEMBL948546 | 0.75 | S1PR1 (0.55) | S1PR1S1PR5S1PR4 | |
| SCHEMBL949792 | 0.73 | S1PR1 (0.34) | S1PR1S1PR5S1PR4 | |
| SCHEMBL951026 | 0.71 | S1PR1 (0.74) | S1PR1S1PR5S1PR4 | |
| SCHEMBL948843 | 0.71 | ESR2 (0.38) | S1PR1OPRK1 | |
| SCHEMBL2446506 | 0.70 | S1PR1 (0.46) | S1PR1S1PR5S1PR4 | |
| SCHEMBL2446502 | 0.70 | S1PR1 (0.46) | S1PR1S1PR5S1PR4 | |
| SCHEMBL12320236 | 0.70 | S1PR1 (0.46) | S1PR1S1PR5S1PR4 | |
| SCHEMBL2017262 | 0.68 | S1PR1 (0.53) | S1PR1S1PR5S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |