Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL949792 | 0.92 | S1PR1 (0.34) | ESR2HTR6MIFS1PR1 | |
| SCHEMBL948567 | 0.84 | NR1H2 (0.32) | MEN1KMT2ANR1H2NR1H3GPR119 | |
| SCHEMBL948569 | 0.84 | NR1H2 (0.32) | MEN1KMT2ANR1H2NR1H3GPR119 | |
| SCHEMBL14321088 | 0.81 | S1PR1 (0.44) | S1PR1 | |
| SCHEMBL2017781 | 0.81 | S1PR1 (0.44) | S1PR1 | |
| SCHEMBL946678 | 0.78 | S1PR1 (0.45) | ESR2HTR6MIFS1PR1 | |
| SCHEMBL948764 | 0.76 | S1PR1 (0.63) | S1PR1 | |
| SCHEMBL947762 | 0.75 | S1PR1 (0.64) | S1PR1 | |
| SCHEMBL949133 | 0.71 | S1PR1 (0.41) | S1PR1OPRK1 | |
| SCHEMBL2446502 | 0.69 | S1PR1 (0.46) | MIFS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |