SCHEMBL9491970

SCHEMBL9491970

FC(F)(F)Oc1ccc(C(CCCc2cccc(Oc3ccc(Cl)cc3)c2)C(F)(F)F)cc1

nearest known ligand 0.50

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FDFT1 P37268 10/20 0.50
CNR1 P21554 1/20 0.43
CETP P11597 7/20 0.43
TRPV1 Q8NER1 1/20 0.40
PPARG P37231 1/20 0.40
PPARA Q07869 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7934874 0.92 FDFT1 (0.53) FDFT1CETPPPARGPPARA
SCHEMBL9492405 0.92 CETP (0.50) FDFT1CETP
SCHEMBL7930475 0.83 FDFT1 (0.52) FDFT1CETP
SCHEMBL9804452 0.83 CETP (0.49) FDFT1CETP
SCHEMBL9560416 0.82 CETP (0.43) CNR1CETPPPARGPPARA
SCHEMBL9804389 0.82 FDFT1 (0.45) FDFT1CETP
SCHEMBL9804456 0.81 FDFT1 (0.54) FDFT1CETP
SCHEMBL7934863 0.81 DRD2 (0.46) FDFT1CNR1PPARGPPARA
SCHEMBL9804343 0.81 FDFT1 (0.58) FDFT1CETP
SCHEMBL9804359 0.81 KDM4E (0.50) FDFT1CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0279531-B1 PROCESS AND INTERMEDIATES FOR THE PREPARATION OF INSECTICIDALLY ACTIVE COMPOUNDS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-03-10 EP disclosed
US-5081273-A PROCESS FOR THE PREPARATION OF INSECTICIDALLY ACTIVE DIPHENYL ETHER COMPOUNDS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-01-14 US disclosed
US-4942264-A WITTIG REACTION FOLLOWED BY REDUCTION IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-07-17 US disclosed
EP-0279531-A2 Process and intermediates for the preparation of insecticidally active compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-08-24 EP disclosed